The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level by Jessica Wapner

the philadelphia chromosome jessica wapner

The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level by Jessica Wapner – Expected Publication: May 14th, 2013 
Publisher: The Experiment
Source: Publisher

One of the first books I read on my Kindle was The Immortal Life of Henrietta Lacks. Though I’m not much of a technical science person, I was attracted to the history aspect of the story and was hoping there would be a good blend of both. I was surprised to find how quickly I flew through to 100% (oh, the exciting new world of e-reading!) in a science-related book. Henrietta Lacks was soon followed by Stiff and The Emperor of All Maladies, until I realized I’m pretty fond of narrative non-fiction in the science realm.

The major topic of The Philadelphia Chromosome, the discovery of a cancer causing genetic mutation known as chronic myeloid leukemia (CML), was actually touched on briefly in The Emperor of All Maladies. However, Jessica Wapner uses the entirety of her book to focus on the connections between genetics and cancer, from the late 1950’s through a series of breakthroughs that have allowed thousands to survive what would have once been a fatal diagnosis.

The Philadelphia Chromosome works well because of its balance. It never reads like an overly technical textbook, nor does it fall into a wordy history or weepy biography. Wapner uses the personal stories of patients who were able to survive by taking a daily pill to piece together the history of genetic cancer research. While the science behind the success is described, it is broken down in a way that readers unfamiliar with the details of genetics can easily understand. 

Though parts of the book did read rather similar to The Emperor of All Maladies, I didn’t necessarily feel like I was reading the same information over again. In fact, I would recommend reading it prior to reading The Philadelphia Chromosome, since it provides readers with a good groundwork in the history of cancer research that Wapner’s book can easily build on.

  • This one doesn’t sound like the exact book for me but I really, REALLY, liked The Immortal Life of Henrietta Lacks :)

  • I love good narrative science writing. And I loved The Emperor of All Maladies a lot, which makes me very curious about this one.

    • You’d probably really like it! It’s similar in style to The Emperor of All Maladies, but more focused and not quite as long.

  • I haven’t read either TEoAM or TILoHL, but I have Philadelphia Chromosome on my Nook to start soon. Glad to see you liked it!

    • I’m sure you’ll enjoy it even if you haven’t read the others. The style is easy to follow and it’s a great story!